Technologies

BSV has developed core competency in developing New Drug Delivery Systems for existing drug which:

>>  Significantly reduce the toxicity of the existing drugs (as in case of a few oncology drugs)
>> Significantly enhance the half-life of the products in the blood, which means that the drug can be effectively targeted.
>> Significantly improve the handling properties of the drug, for example Lipid free Propofol.
>> The manufacturing process yields a cost effective product, which effectively means that the drug can be made available to the patients at a very affordable cost.
>> The technologies developed are patentable and would not infringe upon the existing technologies. BSV has been cleared by PCT on 3 of its patent and another 7 applications are at various stages of filing and registration.


The USP’s of the various products in pipeline are as follows:

Liposomal Doxorubicin (non-pegylated)
>> Reduced cardiac toxicity when compared to Doxorubicin (Adriamycin)
>> Longer half-life in the blood
>> Absence of hand foot syndrome evident in pegylated Liposomal doxorubicin
(Doxil/Caelyx)
>> Ready to use formulation, as against three-step preparation in the only other
non-pegylated Liposomal Doxorubicin approved for marketing. (Myocet)
>> Patent Status: Provisional Patent filed
Cisplatin Emulsion
>> Reduced renal toxicity when compared to Cisplatin
>> Tumour bearing studies onging (in US)
>> Patent Status - Indian Patent Granted and PCT Applications filed in various countries for entering National Phase filing
Amphotericin B Emulsion
>> Reduced nephrotoxicity as compared to conventional Amphotericin B
>> Enhanced uptake by RES system, hence more effective in conditions like
Leishmaniasis
>> Lower therapy cost as compared to Amphotericin B lipid complex &
Liposomal Amphotericin
Amphotericin B Lipid Complex
>> Reduced nephro / hepato toxicity
>> Novel manufacturing process, obviating use of solvents ( e.g. DMSO)
>> Patent Status – Indian Patent Granted and the PCT office examination report to be received
Propofol Lipid Free
>> Enhanced Physical Stability
>> Clear solution - hence physical inspection and sterile filtration possible
>> Ease of administration
>> No hypercholesteremia / hypertriglycridermia
>> No embolism
>> Reduced chances of contamination
>> Patent Status – Indian Patent Granted and PCT Applications filed in various countries for entering National Phase filing

 
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